A negative blood type and von willebrand

all pВ <В 0.001), whereas a negative relationship was observed for ADAMTS13 antigen ( rВ =В 0.306 pВ =В 0.006). Moreover, FVIII:C, Fbg, VWF:Ag, VWF:CBA, and VWF:Rcof showed significant and positive relationships with age ( rВ =В 0.421, 0.445, 0.410, 0.401, and 0.589, resp. Other than ADAMTS13 ( pВ <В 0.01), no gender-related variations were observed in the other parameters. ADAMTS13 antigen decreased with increasing age, whereas the other parameters increased. Mean FVIII:C and VWF levels (VWF:Ag, VWF:CBA, and VWF:Rcof) were significantly higher in non-O than in O type subjects ( pВ <В 0.05 for all comparison). VWF antigen (VWF:Ag), collagen-binding activity (VWF:CBA), and ADAMTS13 antigen were assessed by ELISA, whereas VWF ristocetin cofactor activity (VWF:Rcof) was performed by agglutination of platelets with ristocetin. FVIII:C and Fbg were measured by clotting assays. ABO blood group was determined by indirect technique. MethodsДЄ total of 290 healthy volunteers were eligible for this study. We investigated the effects of ABO type, age, and gender on plasma levels of FVIII, Fbg, VWF, and ADAMTS13 in a Chinese population.

Age and gender have been shown to influence FVIII, VWF, fibrinogen (Fbg), and ADAMTS13 (A disintegrin and metalloprotease with thrombospondin type 1 motif, 13). PeerJ 5: e3156 ДЄBO blood group is a hereditary factor of plasma levels of coagulation factor VIII (FVIII) and von Willebrand factor (VWF). Influences of ABO blood group, age and gender on plasma coagulation factor VIII, fibrinogen, von Willebrand factor and ADAMTS13 levels in a Chinese population. Cite this article Wang Z, Dou M, Du X, Ma L, Sun P, Cao H, Ye S, Jiang P, Liu F, Lin F, Zhang R, Li C. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited. Licence This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. Institute of Blood Transfusion, Chinese Academy of Medical Sciences & Peking Union Medical College, Chengdu, Sichuan, China DOI 10.7717/peerj.3156 Published Accepted Received Academic Editor Hendrik Feys Subject Areas Biochemistry, Global Health, Hematology, Translational Medicine Keywords ABO blood group, ADAMTS13, Coagulation factor VIII, Von Willebrand factor, Age, Fibrinogen, Gender Copyright В© 2017 Wang et al.

A negative blood type and von willebrand